PEGylated Mechano-Growth Factor is a modified form of MGF, itself a modified form of IGF-1. Research has shown it to lower cholesterol and total body fat, boost immune function, and improve rates of wound healing.
Overview
Pegylated Mechano-growth factor (PEG-MGF) is a truncated and slightly altered form of insulin-like growth factor 1 (IGF-1). Research shows that it stimulates myoblast (muscle cell) proliferation and differentiation. It has also been explored in research focused on increasing endurance, boosting the function of the immune system, lowering cholesterol, and reducing total body fat. There is also some evidence to suggest that PEG-MGF improves immune function related to healing and could therefore less the time it takes for wounds to heal.
Research
Injuries to muscle are common in sports and include everything from strains and sprains to outright avulsion injuries. In many cases, these types of injury require surgical repair. Regardless of the treatment, however, recover tends to be long and results are not always perfect. Research in a mouse model of muscle injury, however, suggests that MGF injected directly into muscle protects the cells by decreasing expression of certain inflammatory hormones, and reducing oxidative stress[1].
Similar research by Sun et. al. shows that MGF modulates muscle inflammation and improves the recruitment of macrophages and neutrophils to the site of injury[2]. Both studies are based on the previous knowledge that exercise-induced muscle damage stimulates the release of IGF-1Ea and IGF-1Eb, both of which are closely related to MGF.
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