LL-37 is a human antimicrobial peptide that plays a key role in immune defense, tissue healing, and inflammation control.
Overview
LL-37 is a naturally occurring peptide from the cathelicidin family, produced by white blood cells and epithelial cells as part of the body’s innate immune response. It has broad-spectrum antimicrobial activity, meaning it can neutralize bacteria, viruses, and fungi, offering protection against infection.
Besides fighting microbes, LL-37 also promotes wound healing, modulates inflammation, and supports tissue regeneration. These properties make it valuable in clinical research and experimental treatments for chronic wounds, respiratory conditions, and inflammatory skin diseases.
Research
Scientific studies have shown that LL-37 not only kills pathogens but also helps regulate immune responses. It acts by disrupting microbial membranes and signaling immune cells to repair damaged tissue, making it useful in wound care and immune-compromised scenarios.
Research is ongoing into LL-37’s potential as a treatment for antibiotic-resistant infections, psoriasis, and even certain cancers. Early results are promising, though more clinical trials are needed to validate its safety and therapeutic effectiveness in long-term human use.
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